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Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients towards the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation. Acamprosate also functions eliminate the want to drink through the elimination of the the cravings for drinking alcohol. The major difference between Naltrexone and Acamprosate is the fact that Acamprosate is just not yet available in the United States. While it has become widely studied in Europe the exact chemical reason that it works continues to be unknown. It is believed that it disrupts receptors inside the brain which process glutamate, which in effect alters the best way ones body reacts to alcohol intake. Several of the European studies show a lot of promise with Acamprosate in that some of the patients had a practically double success rate for staying sober.

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