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Liver disorders--alcoholic hepatitis Gastrointestinal problems--chronic inflammation of the lining in the stomach and small intestine Cardiovascular problems--risk of heart failure Diabetes complications--lowers blood glucose levels Sexual problems in males Menstruation problems ladies Birth defects--fetal alcohol syndrome and also other defects Bone loss--thinning of bones and probability of fractures Neurological problems--numbness and tingling from the hands and feet, may also lead to dementia Increased likelihood of cancer in the esophagus, liver, larynx and colon. Deficiency of CREB gene, rats increased drinking fifty-percent more alcohol, and anxiety behavior was higher. Acamprosate calcium (Or Campral, manufactured by Forest Laboratories) utilized in Europe to avoid relapse in alcoholics, and US Food and Drug Administration approved the application, on July 29, 2004. 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